DRAFT: DO NOT SHARE

What is the ECS?

The endocannabinoid system (ECS) is an integral biological system in our bodies and other mammals, composed of a group of endocannabinoids such as Anandamide, and they are made in the body. This system regulates and controls many of our critical bodily functions, including the 11 other systems in the body including the immune, digestive, skeletal, muscular.

It plays a role in regulating body processes from sleep, to pain sensation, mood, appetite regulation, immune function, brain plasticity, learning and memory, neuronal development, sensory system, inflammation, digestion, metabolism, energy balance, cellular system, and regulation of stress and emotions.

It is a complex system that isn’t fully understood, but it is clear that dysregulation or deficiency is linked to a wide variety of illnesses. The ECS is associated with brain plasticity and circuit repair.

When something has been in our culture for so long and clearly has health benefits, it shouldn’t be banned or made illegal just because a big company sees it as competition, especially if that company is making synthetic versions of products.

Endocannabinoid System w/ the 11 systems it regulates

CB1 and CB2 receptors with cannabinoids CBN, THC, and CBD

What are receptors?

Receptors are like locks which wait for keys to do different things with the things that connect to them, sending information into and sometimes out of cells. Many types of receptors are present in the body and have many different functions. Endocannabinoids and Phytocannabinoids both can fit into the CB1 and CB2, cannabinoid receptors which are present in most organs of the body.

What is Cannabis?

The plant has been used for thousands of years in cultures around the world with only positive results. The scientific name is Cannabis Sativa L., named by Carl Linnaeus in 1753.

Recently, in the last hundred years, it has been greatly misunderstood and misrepresented and before this time the plant was used for many things in most of our cultures, including as food, clothing, medicinal preparations, fuel, and many other things. In the United States it was a staple material for the founding of the Colonies and the formation of the USA, as a foundational food, material for ropes and sails, books and clothing, and a medicinal plant for many ailments of which todays pharma medicine is less efective and has more side effects.

Anandamide Molecule – The bliss molecule

Endocannabinoids

Produced from within the body and are fatty acid derivatives, which are endogenous (from the body) lipid-based (fats) retrograde (information goes backwards) neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the central nervous system (CNS). Kind of like a computer sending information both ways and gaining more information to preform a better program or in this case a more functional body. Some of these include AnandamidDe and Arachidonic acid, which come from the body and help us achieve better nutrition, strength, focus, and more.

Phytocannabinoids

Produced from a plant and can be found in plants such as Cannabis, rhododendron, licorice and liverwort, and in Echinacea. Multi-ring phenolic compounds. They include CBG, THC, CBD, CBN and more.
Specifically, CBN is called Cannabinol, THC is known as Tetrahydrocannabinol, CBD is Cannabidiol, and CBG is Cannabigerol. There are dozens of others that are also present. These aid in our bodies to function in an optimal levels.

Tetrahydrocannabinol molecule

Cannabinoid receptors in the body

CB1
The CB1 receptor, also known as the cannabinoid receptor type 1, is a G-protein coupled receptor that is abundant in neurons and plays a crucial role in modulating neurotransmission. It is primarily found in the central nervous system (CNS) and is activated by endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), as well as by plant-derived phytocannabinoids like tetrahydrocannabinol (THC).

The CB1 receptor is involved in various physiological processes, including memory and learning, and has been implicated in several disease states, including addiction disorders, motor dysfunction, schizophrenia, and mood disorders such as depression and anxiety. It is also expressed in the peripheral nervous system and has been linked to various physiological processes, including pain modulation and inflammation.

The CB1 receptor is a seven-transmembrane G-protein coupled receptor that is coupled to Gαi/o proteins, which inhibit adenylate cyclase and decrease cAMP levels. Activation of the CB1 receptor also leads to the inhibition of voltage-gated calcium channels and the activation of potassium channels, resulting in a decrease in neuronal excitability.

CB2
The cannabinoid receptor 2, is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene.[5][6] The principal endogenous ligand in the body for the CB2 receptor is 2-Arachidonoylglycerol (2-AG).[6]

It is closely related to the cannabinoid receptor 1 (CB1), which is largely responsible for the inhibition of the psychoactive properties of tetrahydrocannabinol (THC). [5][7]